It was the final Hammer production to be made at Bray Studios, the company's home until 1967, when its productions moved to Elstree Studios and occasionally Pinewood.
Special visual effects for the film were created by a team headed by veteran visual effects artist Les Bowie, who worked on numerous Hammer productions and several notable British-made science-fiction features.
The film was released as a double bill alongside fellow Hammer production Crecendo.
As with most of the Hammer productions, the film was shot at Bray Studios on a modest budget.
Many of the exterior sets utilised were on the studio's backlot and had already been used for many Hammer productions previously.
Black Park was featured in numerous Hammer productions due to its atmospheric appearance on film and its proximity to Hammer's Bray Studios base.
The last Hammer production made at Bray was The Mummy's Shroud, which wrapped on 21 October 1966.
Although Count Dracula stars Christopher Lee in the title role, it is not a Hammer production like his other Dracula films, being produced instead by Harry Alan Towers.
Quatermass 2 was, however, the first film Hammer pre-sold the distribution rights in the United States, a financial model that would quickly become the norm for subsequent Hammer productions.
As well as shooting on location, Guest and his crew made use of Stages 2 and 5 of the New Elstree Studios, the first Hammer production to shoot there.