He married Elizabeth Hamilton, daughter of James Hamilton, 1st Lord Hamilton in 1459.

He married Harriet Hamilton (1812-1884), daughter of James Hamilton, Viscount Hamilton, in 1836.

He married Margaret Hamilton, daughter of James Hamilton of Bangor and Sophia Mordaunt.

He was the only surviving son of Michael Ward and his wife Anne Catharina Hamilton, daughter of James Hamilton.

In 1709, he married Anne Catharine Hamilton, daughter of James Hamilton.

She was the daughter of James Hamilton, 1st Duke of Abercorn and Lady Louisa Jane Russell.

He married, firstly, Helen (died in or before 1541), daughter of James Hamilton, 1st Earl of Arran, and Janet Bethune.

He married his cousin Catherine Hamilton, daughter of James Hamilton, Lord Paisley, but had no children.

He married Agnes, daughter of James Hamilton of Finnart in 1536 at Craignethan Castle.

James was first married in 1529 to Jean Hamilton, an illegitimate daughter of James Hamilton, 1st Earl of Arran.