I think the despair is coming from our souls.

When the despair came, Reah feared that the past was returning again.

"You toy with me," she said, the sadness and despair come back into her voice, replacing the otherwise-always-present anger.

I don't understand where the despair comes from.

With an effort of will, he continued, "Then despair came upon us.

And the despair that he had been holding off came crashing down on him.

All the old anguish and despair came back.

Then came more despair in the bottom of the 11th.

The despair in her eyes had not come from the knowledge of impending death, but of regret for things not done.

And close on the heels of the exhaustion came despair and self-pity.