Mice lacking GCLM demonstrate no outward phenotype, but exhibit marked decrease in GSH and increased sensitivity to toxic insults.

These agents decrease the metabolic demand of the renal tubular cell, reducing its oxygen requirement and hence increasing its resistance to ischemia [ 46] and perhaps to other toxic insults as well.

These changes can be caused by toxic insult, thrombosis, neoplasia or DIC (disseminated intravascular coagulation).

Nonalcoholic toxic insults include administration of certain chemotherapeutic agents, particularly doxorubicin (Adriamycin), and cobalt.

As one of the two major spectroscopic techniques used in metabolomics, NMR is used to generate metabolic fingerprints from biological fluids to obtain information about disease states or toxic insults.

Additionally, none of U.S. EPA's calculations account for the extra vulnerability of the unborn fetus and children to toxic insults.

Type I pneumocytes are unable to replicate and are susceptible to toxic insults.

As well as being induced by developmental control processes, apoptosis can also be induced by toxic insults, and, in particular, by agents that damage DNA.

Type 2 pneumocytes are important in that they can proliferate and differentiate into type 1 pneumocytes, which cannot replicate and are susceptible to a vast numbers of toxic insults.

The clearing of the inflammation and eventual patient outcome is related to the severity of the toxic insult at the time of surgery.