"guide" in inglés with examples - Collocation dictionary inglés
- RNA editing, in which an RNA sequence is altered by a complex of proteins and a "guide RNA", could also be considered an RNA-to-RNA transfer.
- Herein lies the only known function of the minicircles - producing guide RNA (gRNA) to decode this encrypted maxicircle information, typically through the insertion or deletion of uridine residues.
- Pan-editing starts with the base-pairing of the unedited primary transcript with a guide RNA (gRNA), which contains complementary sequences to the regions around the insertion/deletion points.
- The mechanism of the editosome involves an endonucleolytic cut at the mismatch point between the guide RNA and the unedited transcript.
- The complex can act on only a single guide RNA at a time.
- Therefore, a RNA transcript requiring extensive editing will need more than one guide RNA and editosome complex.
- It is an unusual guide RNA in that it its composed of both H/ACA box and a C/D box conserved domains.
- It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
- It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA' as it 'guides' the modification process.
- The insertions and deletions are mediated by short guide RNA (gRNAs) which encode the editing information in the form of complementary sequences (allowing GU as well as GC base pairs).
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