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Likewise, the carcinogenic action of bile may be related to the duration of exposure of gastric mucosa to biliary carcinogens.
A linear low-dose extrapolation approach was used to estimate human carcinogenic risk from TCE exposure for kidney cancer due to the mutagenic mode of carcinogenic action.
Carcinogenic action in nasal mucosal cells due to inhalation exposure is suspected, due to observed genotoxicity in human tissue samples, and in rat livers the evidence of increased pre-neoplastic lesions raises concern over oral exposure.