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By now, however, a substantial change had taken place from those earlier days.

More substantial changes are made toward the end of the story.

All the substantial political changes have been put in place.

Substantial changes were made to the house in the 1830s.

There have been no other substantial changes to the building.

White did not design the house but made substantial changes while living there.

It is early yet to be sure of substantial change.

The hundred years had really made substantial changes in all of them.

I therefore feel that the time has come for substantial changes.

While the school would not see any substantial changes until the early 2010s, planning began several years earlier.

At the end of the 20th century the last major changes took place.

We may have to make a major change in what we're doing.

Three major changes came about as a result of the plan.

The most recent major change was between 1994 and 1998.

We are making major changes to our system with little of a real game plan in evidence.

The program will likely lead to major changes in many of the city's public high schools.

The set for the show has had two major changes over the years.

But major changes were made in the early 20th century.

We've gone through a major change of government since then.

They are likely to make major changes during the off season.

You obviously are dealing with some serious changes right now.

So again, this is the beginning of what feels like some serious change.

There are going to be some serious changes around here now, and it's best you two understand that immediately.

Still, he says, serious changes are needed if the club is to endure into the next century.

But the serious change he'd like to make is to be taller.

Any deal would have required serious changes in agriculture by many nations.

The past 50 years have faced far more serious change to the world's ecosystems than has ever been seen before.

"I like that there were no serious mental changes in me from moving here."

At the same time, there was a serious change of style.

I would take her dishes and make very serious changes to them.

If it's not the sensors, there will be severe local changes.

Obviously, a horseshoe also gives rise to a severe change in direction, while a spiral generally does not.

Potentially severe changes in the Earth's climate might then ensue.

More severe changes aren't likely to occur during a short period of watchful waiting.

It is characterized by severe changes in temperature, high winds and the deep winter snow.

He thought that strong ties are very important in severe changes and uncertainty.

A. When they're starting to see severe changes in behavior beyond what is the norm for that kid.

Women with less severe changes may have premature menopause or difficulty becoming pregnant.

However, some lesions can progress to large sizes and cause severe changes in the patient's quality of life.

Sethu realizes that the world around him has undergone a severe change.