premunition

However, premunition is probably much more complex than simple antibody and antigen interaction.

Thus, if an individual departs from an endemic area, he or she may lose premunition and become susceptible to malaria.

For malaria, premunition is maintained by repeated antigen exposure from infective bites.

Premunization is the artificial induction of premunition.

Antibody action contributes to premunition.

In the case of malaria, the sporozoite and merozoite stages of Plasmodium elicit the antibody response which leads to premunition.

However, Plasmodium can change its surface antigens, so the development of an antibody repertoire than can recognize multiple surface antigens is important for premunition to be achieved.