At the moment protein A is so scarce it costs between £5 and £10 a milligram.
Charles Brown, professor of microbiology at Heriot-Watt University received about £30 000 from Speywood last year to develop a method of producing protein A continuously.
In the case of S. aureus protein A, immunoglobulins are captured on the microbial surface and camouflage bacteria during the invasion of host tissues.
PVL may increase the expression of staphylococcal protein A, a key pro-inflammatory factor for pneumonia.
To one drop of blood, a drop of antibody solution to protein A (anti-A) is added.
Speedy protein A is a protein that in humans is encoded by the SPDYA gene.
The capacity of protein A to bind antibodies with such high affinity is the driving motivation for its industrial scale use in biologic pharmaceuticals.
The protein A used for production of antibodies in bio-pharmaceuticals is most commonly bound to a stationary phase chromatography resin.
This outcome has been associated with an immunodominant T cell epitope of outer-surface protein A (OspA) of the spirochete.
Immunocomplexes were collected by binding to protein A or G beads, washed and analyzed by immunoblotting as described [ 33].