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Beta-blockers should be avoided in patients with a history of asthma or bronchospasm; if there is no alternative, a cardioselective beta-blocker can be used with extreme caution under specialist supervision.
Specialist supervision is available over a wide spectrum of periods (from palaeolithic to the early historic) and a broad range of regions (from Scotland, across Europe, including central and eastern Europe, to the Mediterranean and the Middle East).
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