The entire band appeared as themselves in the American Dad episode, "My Morning Straitjacket", which aired on November 22, 2009.

Joe Nakash was referenced in the American Dad episode called Hot Water.

The song was used in the American Dad episode "The Boring Identity".

Truglio provided the voice of Freddy in the American Dad episode "Stan's Best Friend".

Gellar then guest-starred in the American Dad episode "Virtual In-Stanity" (aired on November 20, 2011), which brought 4.82 million viewers.

The season 8 American Dad episode "Blood Crieth Unto Heaven" has this playing on the gramophone in one scene.

Simon appears in American Dad episode The One That Got Away with the family becoming addicted to the game, playing it for days without moving.

In the American Dad season 9 episode "Killer Vacation", Steve mentions maggot therapy when his friend suggests using bees to clean his open wound.

A version was sung in the American Dad episode titled "With Friends Like Steve's".

American Dad episode, Killer Vacation briefly mentions 404 in a class for making hip-hop necklaces.