Trifluoperazine is contraindicated in CNS depression, coma, and blood dyscrasias.

Overdosage symptoms are paradoxical, ranging from CNS depression to stimulation.

In adults, overdose usually leads to CNS depression, ranging from drowsiness to coma.

CNS depression has been reported to occur in chronic abusers exposed to high levels of toluene.

CNS depression and death have occurred at higher levels of exposure.

Adverse effects include CNS depression, although paradoxical excitation has been reported.

Other common causes of CNS depression are metabolic disturbances, such as hypoglycaemia.

CNS depression is treated within a hospital setting by maintaining breathing and circulation.

CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination.

CNS depression occurs much more frequently in the elderly and is especially common in doses above 5 mg of nitrazepam.