All patients are initially classified as either standard risk or high risk based on age, presenting leukocyte count, and the presence or absence of CNS disease.

ANG1005 will then possess the potential to treat a variety of CNS diseases including glioma.

The serum cryptococcal antigen is also almost always positive in cases of CNS disease and in other instances of disseminated infection.

The most common and well-studied presentation of cryptococcal infection in HIV-infected patients is CNS disease.

Pulmonary and extrapulmonary cryptococcosis (CNS disease ruled out)

Although focal findings are more typical, the initial presentation can vary and reflect diffuse CNS disease.

Since the beginning of 2009, Biovista has started its own drug development programs based on repositioned compounds in CNS diseases, such as Multiple sclerosis and Epilepsy.

Ocular GME is considered to be an extension of CNS disease.

These patients have a threefold increased risk for developing diabetes insipidus (DI) and an increased risk of other CNS disease (see below).

Because only 5% of patients with AML develop CNS disease, prophylactic treatment is not indicated.