Most died from European diseases to which they had no immunity.
They stayed only one month and were able to return without contracting any European diseases.
They also introduced European diseases that the native people had no immunity against.
Many were killed or died as a result of European diseases.
Someone referred to the European disease that was sweeping the country.
Some historians argue that European disease did not appear to be a serious factor until after 1829.
By the early 17th century their numbers were reduced to several hundred by European diseases.
That is why it is very much a European disease growing in prevalence.
European diseases had a devastating impact on the native people of Guatemala.
But other possibilities, including climate change and exposure to European diseases, may have been equally important.