Interstate 15 crosses Lake Hodges via the Lake Hodges Bridge.

U.S. Route 18 passes along the southern edge of the watershed, and Interstate 94 crosses through it from east to west.

Interstate 90 crosses through the reservation with the closest exit being in Irving, New York.

Interstate 71 crosses over Alum Creek immediately south of the Alum Creek Lake recreation area.

Interstate 44 crosses on the Missouri half, however, it is unsigned.

Interstate 95 crosses through Norwalk, and there are several exits within the Norwalk city limits.

A portion of Interstate 495 crosses through the eastern side of town from Lawrence to Haverhill.

Interstate 90 crosses Lake Washington between Seattle and Bellevue on a pair of floating bridges that are two of the world's longest floating bridges.

Interstate 95 crosses through the eastern corner of town, with an exit lying just over the line in Newbury providing access to the town.

U.S. Route 5 borders the east side of East Rock while Interstate 91 crosses below Snake Rock to the south.