Improvements came when the wagon road through the area was redesignated as part of the Jefferson Highway.

The bridge was considered as an option for planners of the Jefferson Highway.

In Port Allen, Jefferson Highway goes north to the northern end of the town.

The ramp's clearance over Jefferson Highway was increased from 14 feet to 17 feet in 2009 to facilitate truck traffic passing underneath.

The Rosedale Library on Jefferson Highway was completed in 1987.

LA 6 then followed into Natchitoches, where it was paired with the Jefferson Highway for a short distance.

A car on Jefferson Highway has an umbrella stuffed in the shattered driver's window to hold out the rain.

The Jefferson Highway was designated as US 99E in 1926.

OR 164 was assigned to the Jefferson Highway in 2002.

The route retains the name of Jefferson Highway east of Kenner.