In the 5th century BC Atalanti was annexed in the Macedonian Kingdom and by that time it followed the Greek history.

In the Treaty of Phoenice, 205 BC, Atintania was assigned to the Macedonian Kingdom.

Later, it joined the Macedonian Kingdom under Philip II.

After the defeat of the Macedonian Kingdom, Pharsalos and the whole area became a part of the Roman Republic.

Cletius managed to escape and kept his throne, probably as a vassal under the Macedonian Kingdom.

This combination of cavalry and infantry helped to break enemy lines and were used effectively to dominate the opponents of the Macedonian Kingdom.

Some remained under the control of the Macedonian Kingdom and until 146 BC, when the Greek peninsula was gradually annexed by Rome.

In the intervening period, the poleis of Greece were able to wrest back some of their freedom, although still nominally subject to the Macedonian Kingdom.

The Loutrochori area has been a spa from the 4th century BC under the Macedonian Kingdom.

In 349/8 BC the city had the fate of the other cities of Chalkidiki, that is, it became part of the Macedonian Kingdom.