Today most of the town's businesses are located at the south end on Missouri Route 7.

The road continues as Missouri Route 126 and heads toward Springfield.

After I-35, 210 immediately intersects Missouri Route 1 and continues east.

There is a concurrency with Missouri Route 100 through Hermann.

Through Owensville there is a concurrency with Missouri Route 28.

It forms a concurrency with Missouri Route 8 through Steelville.

Missouri Route 73 is a short state highway in southwest Missouri.

Milan was a small town much like his native Keytesville, which is about fifty miles to the south on Missouri Route 5.

It was renumbered to provide route number continuity with Missouri Route 5.

Florence is located 8 miles south of US 50 on Missouri Route 135.