The original numbered designation of this route, which appeared on Nevada Highway maps as far back as 1919, was State Route 2.

The primary routes to Lake Tahoe are on Interstate 80 via Truckee, U.S. Highway 50, and Nevada Highway 431 via Reno.

California Highway 28 completes the circuit from Tahoe City around the northern shore to communities such as Kings Beach, Crystal Bay, and into Incline Village, Nevada where the road becomes Nevada Highway 28.

Vehicle travel is allowed in only one direction through Titus Canyon, from Nevada Highway 374 (Daylight Pass Road, 2 miles east of the park boundary) to the western end of the canyon.

The Alan Bible Botanical Garden is a desert botanical garden located at the Alan Bible Visitor Center, Lake Mead National Recreation Area, 601 Nevada Highway, Boulder City, Nevada, USA.

But by the time this new route opened, it had been signed as mainline US 93, with the old, winding route of US 93 on the Nevada Highway (original SR 26) through town being changed to SR 500.

The town lies approximately three hours drive north of Las Vegas along Nevada Highway 375 (the "Extraterrestrial Highway"), which has an unofficial "speed limit" of Warp 7.

The major highways/roads serving North Las Vegas are I-15, Clark County Highway 215, and Las Vegas Boulevard (Nevada Highway 604).

Nevada Highway, $190.8 million of revenue bonds.

Access to the area is by Highway 50, Nevada Highway 839, then to an improved gravel road to the site.