Betterton is located at the mouth of the Sassafras River on the upper Chesapeake Bay.

MD 444 continues north through farmland until the road reaches the small beach community of Kentmore Park on the Sassafras River.

The road crosses the Sassafras River and passes through Georgetown, a community that was burned by the British during the War of 1812.

In 1674, Cecil County was created, and the first courthouse was built near the Sassafras River.

She is located at Georgetown, Maryland, USA, on the Sassafras River.

It is south and east of the North East River, and north of the Sassafras River.

In 1979 Baltimore sank at her dock on the Sassafras River in fifteen feet of water.

The Sassafras River is entirely within the coastal plain.

The Sassafras River is home to many boats and four large marinas, all of which are located near Georgetown, Maryland (map).

MD 299 was paved from Massey to the Sassafras River in 1930.