After administration, peak serum concentrations are reached in about two hours.

Peak serum concentrations (C) are reached one to two hours after administration of the drug.

High serum concentrations of phenylacetate were associated with central nervous system toxic effects.

We also made it clear that both dose and frequency should be adjusted as dictated by serum concentrations.

Peak serum concentrations can be seen 1 to 6 hours after ingestion of an oral dose.

In man, after oral administration of 50 mg 14-C-buformin, the maximum serum concentration was 0.26-0.41 g/ml.

Household exposure to passive cigarette smoking and serum micronutrient concentrations.

Declining serum concentrations exhibit a prolonged terminal phase which does not contribute to drug accumulation.

This results, even in steady state, in a rapid decline in serum concentrations.

By reducing the metabolism of drugs through these enzymes, cimetidine may increase their serum concentrations to toxic levels.