It was a weapon which could only be used by a person who had cast down all defenses against despair.

"America needs your efforts and energy in the fight against poverty and despair," he said.

She has a more effective defense against despair - a cantankerous nature.

He closed his eyes, fighting within himself against grief, guilt, and despair.

Revel in the joy and fight all the harder against despair.

"I don't think so," Mary said tightly, fighting hard against despair.

It was social laughter, an attempt to hammer out a common weapon against despair.

He had to believe that, for it was his only present buffer against overwhelming despair.

The hedge against despair is always a good story.

His work was produced an act of courage and determination, against despair.