Fatalities started to be reported in 1999 in cases where THP had been used in combination with other drugs having analgesic and anti-anxiety effects.

In comparison with the antidepressant drugs, paroxetine and imipramine, delorazepam was found to be more effective in the short-term but after 4 weeks the antidepressants showed superior anti-anxiety effects.

Meprobamate is licensed for the short-term relief of anxiety, although it is not known whether the purported anti-anxiety effects of meprobamate are separable from its sedative effects.

It has anti-anxiety effects and works in conjunction with many benzodiazepines.

Tolerance to anti-anxiety effects develops more slowly with little evidence of continued effectiveness beyond four to six months of continued use.

After a confirmed test of the anxiolytic efficacy in a mouse model, haloperidol, mecamylamine, and ketanserin were applied to determine the pathways aniracetam depends on to exert its anti-anxiety effects.

I didn't doubt the anti-anxiety effects of opiates, but the drugs are not a safe or reasonable treatment for anxiety.

Trazodone also has anti-anxiety (anxiolytic) and sleep-inducing (hypnotic) effects.

Another calming herb is ashwagandha, which has anti-stress and anti-anxiety effects.

A pair of small studies conducted by a maker of GABA supplements in Japan reported that GABA did have an anti-anxiety effect.