Topoisomerase poisons have been extensively used as both anticancer and antibacterial therapies.

The increase in bacterial strains that are resistant to conventional antibacterial therapies has prompted the development of alternative strategies to treat bacterial diseases.

In most cases, 8-12 weeks of antibacterial therapy is required.

Ultimately, the efficacy of antibacterial therapy has to be measured by the rate at which it eliminates the symptoms of the infection.

Specific risk factors include neutropenia, use of corticosteroids, exposure to broad-spectrum antibacterial therapy, and previous pneumonia or other underlying lung disease.

Hence, they are very useful in antibacterial therapy.

Although most of the drugs derived from microorganisms are used in antibacterial therapy, some microbial metabolites have provided lead compounds in other fields of medicine.

Natural products may be useful as a source of novel chemical structures for modern techniques of development of antibacterial therapies.

The effect of antibacterial therapy supports a role for bacteria in the disease mechanism (pathogenesis).