Calypso appears as a secret boss at the end of the video game Spider-Man 2.

Shin: Lin's elder brother appears also as a boss.

He appears as both a boss and a playable character.

Mean Machine appears in the 1995 video game as a boss.

The Timestorm 2009-2099 version of Scorpion appears as a boss.

Scarecrow also appears as a boss in the Game Boy Advance version.

He appears as a boss that the player must defeat when playing as the villain Venom.

He appeared as a boss in a simple Flash-based video game on the Hasbro web site.

He appears as a boss in one of the many solo instances.

He appears as a boss in the game, guarding Jean and Nightcrawler.