In 2002, the Oregon Department of Transportation (ODOT) began assigning route numbers to highways that did not previously have route numbers.

The OR 104 designation was applied to the Fort Stevens Highway in 2002 as part of Oregon's project to assign route numbers to previously unrouted highways.

In 1924, the state of New York created the modern New York state route system by assigning designations to several long-distance highways.

OR 528 was established in 2002 as part of Oregon's project to assign route numbers to highways that previously were not assigned.

OR 222 was established in 2002 as part of Oregon's project to assign route numbers to highways that previously were not assigned, and, as of August 2008, was unsigned, although OR 222 route shields did appear on construction warning signs in 2008.

The highway from Riverside to Charlotte Hall received its state highway designation in 1927 when numbers were first assigned to highways in Maryland.