Their sons played in back-to-back tournaments over the Christmas holidays - the first in Toronto, the second in Ottawa.
Mauresmo has also won three titles this season, even becoming the third player to win the back-to-back tournaments in Berlin and Rome.
Despite the loss, Angola became the first African team to qualify for the knockout stage of back-to-back tournaments.
He came to Australia three weeks ago to adjust to the heat and work on his hard-court game, but then lost first-round matches in back-to-back tournaments.
But Serena, 29, still looks to be in her prime, as she showed with back-to-back tournament wins in Stanford and Toronto.
Calcavecchia, 40, had shared the second-round lead with Begay, who is seeking to become the first player to win back-to-back tournaments this year.
When two of the town's sons lost by slim margins in back-to-back tournaments, it was almost too much to bear.
After the back-to-back tournaments, Youzhny retired in the second round at St. Petersburg.
In recent back-to-back tournaments, the 37-year-old Yugoslav grandmaster took a last place and a first place.
Hewitt has won 15 straight matches after winning back-to-back tournaments in Washington and Long Island.