This was the largest margin of defeat since the series began in 1929 with a 76-0 defeat.
In 1998, the Giants were 3-4 heading into the bye week, then lost the next three games, beginning with a 21-14 defeat at Washington.
The club began their pre-season friendly schedule on 19 June 2010 with a defeat away to Llanelli.
October began with a 3-2 defeat at Grimsby Town.
October began with a 2-1 defeat at Cardiff City.
October began with a 2-0 defeat at Crawley Town.
Ireland began their three-test 2012 summer tour of New Zealand with a 42-10 defeat.
Rome's downward spiral did not begin with an external defeat.
The team's losing streak began with a 20-0 defeat to the University of Chicago.
They began with a defeat at Burnley.