But the big blow came at the hands of science.

His loss would be a big blow to the team.

"All we need is a couple of big blows and those things are going to come down."

I didn't want to drop a big blow when all was going well.

I was just a kid when the big blow came in '26.

Jones, however, would have been the biggest blow had the team lost him.

That could be a big blow to Canada in the long run.

But they did nothing to stop al Qaeda from building up its resources for the big blow on 9/11.

"It's a big blow for the people who are working there."

Still, the loss of Elliott would be a big blow to the team.