All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.
The orthologous protein in mouse is located in the endoplasmic reticulum and binds calcium.
The encoded protein binds calcium and is activated by myosin light chain kinase.
Their name comes from their ability to bind calcium.
The protein binds calcium and is expressed in the central nervous system.
The other group, called annexins, bind calcium and phospholipid (e.g., lipocortin).
Many other proteins bind calcium, although binding calcium may not be considered their principal function in the cell.
They bound calcium in the micromolar range and were greatly reduced in vitamin D-deficient animals.
Members of this protein family have six EF-hand domains which bind calcium.
The ability to bind calcium is therefore pH dependent.