The by-election in Newbury was the first in a string of by-election losses for the Conservative Party.
Labour regained one of its by-election losses, Leicester South, but saw an increased Liberal Democrat majority in the other, Brent East.
Several by-election losses meant that by 1977, Callaghan was heading a minority government, and was forced to do deals with other parties to survive.
Further problems arose in April 1991, when reformists published their own manifesto for democracy and there were by-election losses.
Marcel Proulx resigned as Dion's Quebec lieutenant hours before the Harper government's throne speech, taking the fall for the three by-election losses.
After the by-election loss Newman retired from politics and dedicated herself to charitable work.
It marked the third by-election loss for Labor during this parliamentary term, following on from the 2005 losses in Chatsworth and Redcliffe.
The resignation of Harold Wilson brought James Callaghan to power, however his small majority was eroded with several by-election losses and the government became increasingly unpopular.
His government was defeated after a series of by-election losses led to it losing a Motion of No Confidence in 1891.
However he was later elected MP for Walthamstow West in 1970, reversing the by-election loss to the Conservatives of that seat in 1967.