Although the micronucleus model is appropriate, other factors are likely to contribute towards chromothripsis for various cancer genomes.

Furthermore, cancer genomes are often aneuploid.

With cancer genomes, this usually done by aligning the reads to the human reference genome.

These methods all have their distinct shortcomings due to the very complex nature of cancer genomes.

This technique can rapidly determine the overall methylation status of cancer genomes which is cost and time effective.

In 2008, AML became the first cancer genome to be fully sequenced.

In 2009, Stratton and colleagues reported the first complete cancer genomes, from a lung tumour and a melanoma.

The mutations present in the cancer genome are the direct cause of disease and they define the tumor phenotype.

The first cancer genome was sequenced in 2008 by Timothy J. Ley et.

This method has been used to study the gain or loss of genes in cancer genomes compared to normal genomes.