During his campaign against the Sassanid Empire, he sacked their capital Ctesiphon, but died shortly thereafter.

Next Severus embarked on a war against Parthia, which he concluded successfully with the sack of the Parthian capital Ctesiphon.

At last Artabanus III defeated his rival completely and occupied the Parthian capital Ctesiphon.

During his reign he campaigned, aided by Diocletian, against the Sassanid Empire, sacking their capital Ctesiphon in 299.

The Parthian capital Ctesiphon was sacked by the Roman army, and the northern half of Mesopotamia was restored to Rome.

After solidifying his rule, Severus waged a brief war against the Parthian Empire, sacking their capital Ctesiphon in 197.

Galerius continued moving down the Tigris, and took the Persian capital Ctesiphon before returning to Roman territory along the Euphrates.

The Emperor Carus launched a successful invasion of Persia in 283, sacking the Sassanid capital Ctesiphon for the third time.

In that same year, he captured Seleucia and the Parthian capital Ctesiphon.

The Parthian capital Ctesiphon was sacked by the legions and the northern half of Mesopotamia was annexed to the Empire.