Oxygen, more electronegative than carbon, pulls the electrons in the carbon-oxygen bond towards itself, creating an electron deficiency at the carbon atom.

This method became crucial in studies on organic compounds and was subsequently modified by other research workers over rupture of carbon-oxygen bonds.

It belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds.

It is often used as a source of "H " to generate radicals or cleave carbon-oxygen bonds.

Carbon is used because the strength of a carbon-oxygen bond is greater than that of the iron-oxygen bond, at high temperatures.

This strengthens the metal-carbon bond, but also weakens the carbon-oxygen bond.

Type I dyotropic rearrangements also occur around carbon-oxygen bonds.

Amides are the most stable of the carbonyl couplings due to their high resonance stabilization between the nitrogen-carbon and carbon-oxygen bonds.

This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds.

They are also used in organic synthesis to generate radicals or cleave carbon-oxygen bonds.