In his handwritten data, carefully charted in gray hardcover notebooks, lay the origins of what every pharmaceutical company longs for: a blockbuster drug.

His weight has since dropped from 248 pounds to 225 pounds and his progress, toward a goal of 180, is carefully charted on a poster in the music room.

It had been decided not to risk any landings nearer the Ridge until the full extent of the cutout zone had been carefully charted.

After more than two years of sophisticated surveying, guided by signals from Defense Department satellites, the tunnel's path has been carefully charted.

They have no idea where the Ancients went but they have carefully charted the systems that held Guardians.

Lately, in the mornings, he would read only the Sports section, concentrating his full attention on the pages in the back where box scores and statistics were carefully charted and updated each day.

It would have evolved along lines carefully charted by Colonel North and private arms dealers.

But he did not make any pretense that this was a carefully charted course.

This handy glove-compartment guide contains carefully charted maps, must-see attractions, and places to eat and sleep that are slices of pure Americana.