For obstruction, it can cause compression in the GI tract from the stomach to colon, compression in urinary system, biliary system, and arteriovenous system.

This causes food and acids from the stomach to leak back - or reflux - into the esophagus.

Also, this drug may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines.

Other tests may be done to find out whether chest pain may be caused by gastroesophageal reflux disease (GERD), the abnormal backflow (reflux) of food, stomach acid, and other digestive juices from the stomach into the esophagus.