After four to six weeks of treatment, he is returned to the same environment that caused the problem in the first place.

"Going into that lab is what caused most of your problems in the first place."

It was never clear what caused the ship to list in the first place.

The problems we try to defeat are usually caused by us in the first place.

This is the quarterback, who caused the play in the first place.

He said the cold weather probably caused the injury in the first place.

Nothing that couldn't wait until he figured out what had caused all this in the first place.

Besides, your parents caused the problem themselves in the first place.

You know what caused his kidney problem in the first place.

"After all, I'm the one who caused the problem in the first place."