With regard to calcium, cell transformation leads to a much reduced calcium requirement for growth.
Animal studies have shown that gene transformations involving the early embryo can be more effective than somatic cell transformations.
"This gene could be one of the common factors in cell transformation, and as such it could be an excellent target for therapeutic intervention."
Inhibition of PP2A activity is a prerequisite for human cell transformation.
In one case, large cell transformation of tumor cells was associated with partial loss of surface CD3.
High extracellular glutamine concentrations stimulate tumor growth and are essential for cell transformation.
In female guinea pigs, Papanicolaou had already noticed cell transformation and wanted to corroborate the phenomenon in human females.
Theoretically, it may be possible to alter those viruses so that they can no longer cause cell transformation.
The persistence of at least part of the viral genome within the cell is required for cell transformation.
Constitutive activation of Stat3 has been associated with cell transformation and cancer progression.