The changes indicate that the gene has been under strong evolutionary pressure in humans.

Frequent changes, often between very different school types, indicate that he found it difficult to gain ground in his profession.

No reason to call, the nurse thought, unless some further change indicated that his aunt was dying.

Name changes usually indicate a turn for the better.

The general change in the atmosphere indicated that it was so.

Still, the recent changes indicate the league believes improvement is in order.

A change in the number to the left of the point indicates major changes, one to the right minor revisions.

Even before the changes, the study indicates, housing was a greater problem for Jobs First participants.

The change of name indicated the shift to a broader agenda than just American authors.

In general I give the text in its final form, but with more important changes indicated.