The fraternity's collegiate chapters participate in a broad range of activities emphasizing brotherhood, service, and music.

Individual chapters or colonies participate in their own community service events.

The chapter also participates in judging Emmy entries at the regional and national levels.

Most chapters participate in local marine science educational events, and hand out free educational resources for teachers and students.

Collegiate and alumnae chapters also participate in various philanthropic events benefiting their communities.

Every Chapter has their own national philanthropy dedicated to a certain cause that many chapters also participate in.

Many chapters participate in one of these events, with the decision being largely dependent on the climate in which the school is located.

The chapter will participate in the federation's national student advertising competition, dubbed the College World Series of Advertising.

Not all chapters of Phi Sigma Epsilon participated in the merger.

On a national level, SLB acknowledges two philanthropies that all chapters participate in.