Females can be "carriers" for an X-linked genetic abnormality, but usually they will not be clinically affected themselves.
Reservoirs of disease are clinically affected fish and recovered covert carriers.
Parents may either be clinically affected or have germline mosaicism.
A detectable mutation in the gene RECQL4 is present in 66% of clinically affected individuals.
It is not clear why some cats become clinically affected with C. felis while others never show any signs.
Generally only calves during their first grazing season are clinically affected, since on farms where the disease is endemic older animals have a strong acquired immunity.
However, clinically affected animals can slobber for several days because they are fed with continued slaframine contaminated forages.
BLiA background, approximately half of the Bmp4 +/-mice were clinically affected and this was always unilateral.
Clinically affected dogs present with splenomegaly, icterus, anemia and thrombocytopenia.
The clinically affected animal has trouble breathing, starts coughing frothy fluid from nostril and mouth, and shows signs of pulmonary edema within four days.