Examinations concluded that the lunula was an area of loose dermis with lesser developed collagen bundles.

Generally, they contain relatively acellular centers and thick, abundant collagen bundles that form nodules in the deep dermal portion of the lesion.

Anchoring fibrils composed of type VII collagen extend from the basal lamina into the underlying reticular lamina and loop around collagen bundles.

Research on nanoscale fibers attempts to mimic the structure of collagen in the extracellular matrix by creating fibers that approach the nanoscale diameter of natural collagen bundles.

Sclerotic fibromas are a cutaneous condition characterized by well-circumscribed, dome-shaped, dermal hypocellular nodules composed predominantly of sclerotic thick collagen bundles.

Substantial collagen bundles anchor the dermis to the hypodermis in a way that permits most areas of the skin to move freely over the deeper tissue layers.

Further ECM abnormalities were present in the peripheral cornea where prominent irregularity of the normally regularly arranged collagen bundles explained the peripheral corneal scleralization.

Both conditions show a proliferation of dermal fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers, and deposits of mucin.

This scar type is sunken, because the collagen bundles do not overextend the tissue.

Patients with classic mitral valve prolapse have excess connective tissue that thickens the spongiosa and separates collagen bundles in the fibrosa.