"Privately or as the mayor, he's come into contact with different issues that influence his philanthropy," Mr. Skyler said.

Here's my promise: if you come with questions or issues, we'll get to them.

Modern plant breeding, whether classical or through genetic engineering, comes with issues of concern, particularly with regard to food crops.

Often these concerns arise when rights come into conflict with other legal or moral issues, sometimes even other rights.

"Some children come with problems and issues so severe, even at very young ages, they disrupt the whole school setting."

"Kids come with different issues," he said.

I believe my colleagues will also come forward with issues.

These men were coming to me with really big emotional issues, and I was comforting them.

Many clients come to the program with issues of substance abuse, mental illness, domestic violence, sexual abuse and poor physical health.