More than a few had probably worked as one or both during the course of their lives.

In the course of my life I've seen everything else take over.

But the course of his life was soon to take a very different turn.

God, he'd let down so many people over the course of his life.

The whole course of their lives would have been changed.

Nor had anyone else during the course of his life.

What has happened to it in the course of its life?

During the course of his long life he was involved in much activity.

He was married to three women over the course of his life.