Entire metabolic pathways could be deactivated by the loss of a critical enzyme [ 7 ] .

Vacuolar type ATPases are housekeeping enzymes critical for the maintenance of homeostasis.

Many of the reduced nitroso intermediates will form sulfinamides and thioether linkages with cysteine-bearing enzymes, thereby deactivating these critical enzymes.

Tyrosinase acts as the critical enzyme in the synthesis of melanin in melanocytes.

Cancer cells mistake antimetabolites for normal metabolites allowing the compound to stop or slow critical enzymes involved in DNA synthesis which then triggers cell death.

In the development of therapeutics and next-generation vaccines, more work is required to determine the structure/ function relationships of critical enzymes and structural proteins.

When quinolinic acid is at pathological concentrations, a reduction of glutamine synthetase, a critical enzyme in the glutamate-glutamine cycle occurs.

This protein is required for the normal function of beta-hexosaminidase A, a critical enzyme in the nervous system that breaks down a lipid called GM2 ganglioside.

T.S.D. is a horrific malady resulting from the baby's inability to produce one critical enzyme (beta-hexosamidinase A) necessary for normal brain growth and development.

Protease is an enzyme critical to the reproduction of the AIDS virus.