Unraveling the riddle of a cruel disease happens to be Dr. Knowles's career preoccupation.

"It's a cruel disease," he said.

Matthew, I later found out, had Muscular Dystrophy, a cruel and debilitating disease which wastes away the muscles in the body.

A cruel disease, as it does not affect the mind.

Alzheimer's is cruel disease that robs its victims of their memories and eventually their functioning brain.

That is the bright side of this very cruel disease.

In fact, this cruel disease is the second most common cause of death in Europe.

Alzheimer's is a cruel disease.

In the last poetry he wrote, MacBeth provides an anatomy of a cruel disease and the destruction it caused two people deeply in love.

They capture the ups and downs of difficult lives, poor families struggling to get by only to be overcome by the devastation of a cruel disease.