Despite her general optimism, Ms. Home does worry about the future.

Despite Cage's optimism, there are signs that it will only get longer.

Despite my cautious optimism, I can't recommend expanded contact at this time.

Despite Terrell's optimism, her tumor got worse requiring more operations.

And Tucker said that James, despite his public optimism, might have to change course.

Despite the company's optimism, the government, it appears, decided to slow the pace and to talk details later.

Despite their optimism, researchers expressed some reservations about the procedure.

I have already been called a Eurorealist for taking that stance, despite my optimism.

Q. Despite your cautious optimism about the business, the last few years must have done some damage to the industry.

Despite the researchers' optimism, all those involved in the start-up acknowledge major challenges.