But by now even more fundamental differences were beginning to appear.

It is time to watch that difference begin to take shape.

But later, after the drug is approved, far more people take it, sometimes along with other drugs, and individual differences begin to show up.

As Express was coming out, a few differences with the rest of her band began to surface.

The difference in energy levels began to show as Nadal took the second set 6-4 and the third 6-1.

Now these differences have begun to emerge and they all point the wrong way.

Over time, though, individual differences begin to become more pronounced.

And as this primary season gets under way, the differences, though subtle, are beginning to be felt here.

But dig a little deeper, and some differences begin to surface.

Actually, the difference began in what might be called the Rome of their history.