Environmental factors also have an impact on disease onset and progression.

Patients generally die within 10-20 years of disease onset.

However, delivery of these agents after disease onset appeared to have only limited therapeutic effect.

CLU-C related variability found here might create a local vulnerability important for disease onset.

In most cases, tympanosclerosis does not cause any recognisable hearing loss up to ten years after the initial disease onset.

Depending on disease onset and severity, type 1 patients may live well into adulthood.

Factors related to age at disease onset (e.g., utilization of screening).

As such, maintenance of proteostasis prevents disease onset.

Reasons for disease onset are not known.

In cases in which there is no associated cancer, disease onset can be at any age.