A short distance past Higdon, the route intersects the southern terminus of SR-73 and makes a turn to the east.

A short distance after the state line, the road intersects the western terminus of DE 44 in Everetts Corner.

A short distance after the circle, the route intersects CR 632 and turns onto Pennington-Lawrenceville Road at that point.

A short distance later, Route 405 crosses under the four lane alignment of Interstate 80 and intersects an old alignment of the Susquehanna Trail.

A short distance down that and they intersected a curving tunnel, the first of the rings of the Labyrinth.

A short distance to the northeast, the route intersects with CR 7 (Halsey Valley Road).

A short distance from the southeastern curve, the route intersects with CR 55 (Harris Hill Road).

A short distance past the state line, Pennsylvania Route 841 intersects the southern terminus of Pennsylvania Route 472.

A short distance past Wijk bij Duurstede, the river intersects with the Amsterdam-Rhine Canal, which continues south towards the Waal.

A short distance to the east, the route intersects with Secatogue Avenue, which connects to the Farmingdale station to the northwest.